In "Smallpox" by D.A. Henderson, readers are taken on a riveting journey through the annals of medical history, exploring the eradication of a disease that had plagued humanity for over three millennia. Henderson, who spearheaded the global campaign against smallpox under the auspices of the World Health Organization, chronicles this monumental battle with infectious enthusiasm and detailed narrative, turning a scientific endeavor into a spellbinding saga of triumph. The eradication of smallpox stands as a testament not only to human resilience but also to the unparalleled achievements that can arise from global cooperation. Henderson's account is not merely a recounting of a successful campaign but an inspiring tale of diplomacy, innovation, and the relentless pursuit of a world free from the scourge of an incurable disease. Beyond the victory against smallpox, Henderson delves into the aftermath and the ongoing vigilance required to safeguard the world from future threats. The discovery of the Soviet Union's biowarfare program and the debates over the destruction of remaining virus stocks add layers of intrigue to a post-eradication world. Henderson's narrative extends beyond smallpox to a broader vision of immunization against common yet deadly diseases, reflecting on the legacy of the smallpox campaign in shaping global health initiatives. "Smallpox" by D.A. Henderson is not just a historical account; it's a compelling call to action, reminding us of the fragility of public health victories and the continuous effort required to maintain them.