In "Little Science, Big Science...and Beyond," Derek J. De Solla Price embarks on a visionary exploration of the evolution and future trajectory of scientific research. Through the lens of the four seminal Pegram Lectures delivered in 1962 at the Brookhaven National Laboratory, Price weaves a compelling narrative that transcends the traditional boundaries of scientific discourse. He presents a meticulously researched analysis of the shift from the quaint, individual endeavors of "little science" to the monumental, collaborative efforts characteristic of "big science." This transition, marked by groundbreaking discoveries and unprecedented technological advancements, raises critical questions about the sustainability, ethics, and societal impact of scientific research. Price's work is not merely a historical account; it is a prescient forecast of the challenges and opportunities that lie on the horizon of scientific exploration. With an elegant blend of scholarly insight and accessible prose, "Little Science, Big Science...and Beyond" serves as a crucial reflection on the nature of scientific progress and its implications for society. Price challenges the scientific community and policymakers alike to reconsider the direction of future research endeavors, advocating for a balance between ambitious scientific objectives and the stewardship of global resources. This book is an essential read for anyone interested in the dynamics of science, its role in society, and its potential to shape our world in the years to come.